Here, evolutionary analysis of both patatins across 46 Rickettsia genomes revealed 1) pat1 and pat2 loci are syntenic across all genomes, 2) both Pat1 and Pat2 do not contain predicted Sec-dependent signal sequences, 3) pat2 has been pseudogenized multiple times in rickettsial evolution, and 4) ubiquitous pat1 forms two divergent groups ( pat1A and pat1B) with strong evidence for recombination between pat1B and plasmid-encoded homologs. However, pat2 is not encoded in all Rickettsia genomes yet another uncharacterized patatin (Pat1) is indeed ubiquitous. The long-standing proposal that phospholipase A 2 (PLA 2) enzymes are involved in rickettsial infection of host cells has been given support by the recent characterization of a patatin phospholipase (Pat2) with PLA 2 activity from the pathogens Rickettsia prowazekii and R.
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